Noah Palm, Ph.D.
Associate Professor of Immunobiology — Yale University School of Medicine
Noah W. Palm, Ph.D., is an Associate Professor of Immunobiology at the Yale University School of Medicine, where his lab focuses on understanding how the trillions of microbes that live in and on us (our microbiota) interact with and influence their mammalian hosts. His work particularly emphasizes the development of new technologies to deconvolute complex host-microbiota interactions and reveal causal roles for the microbiota in human health and disease.
Dr. Palm received his B.A. in Biology from Macalester College and performed doctoral work with Dr. Ruslan Medzhitov and postdoctoral work with Dr. Richard Flavell at Yale University. He is the recipient of multiple honors and awards, including a Smith Family Foundation Award for Excellence in Biomedical Research, Pew Biomedical Scholar Award, and NIH Director’s New Innovator Award.
Featured Publications:
Chen H, Rosen CE, González-Hernández JA, Song D, Potempa J, Ring AM, Palm NW. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell. 2023 Jul 6;186(14):3095-3110.e19. PMID: 37321219. PMCID PMC10330796.
Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature. 2022 Jul;607(7919):563-570.
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. 2022 Oct 28;378(6618):eabm3233.
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW#, Meffre E#. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Science. 2020. 369(6501):320-325. (# Co-corresponding author.)
Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM and Palm NW. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. 2019. 177(5):1217-1231.
Palm NW*, de Zoete MR*, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. 2014. 158: 1000-10. (* co-first author.)