Andrew Wang, M.D., Ph.D., A.B.
Assistant Professor of Internal Medicine – Yale University School of Medicine
Identifying the mechanisms by which modern xenobiotics act as allergic adjuvants
Andrew Wang is an assistant professor in the Departments of Internal Medicine and Immunobiology at Yale School of Medicine. His lab is interested in understanding how the environment impacts inflammatory disease expression to discover pathways that can be therapeutically targeted to treat diseases ranging from sepsis, allergy and autoimmunity to psychiatric diseases like depression. They use mouse models, cell culture, and human samples and apply techniques spanning the disciplines of metabolism, immunobiology, and behavioral biology.
Andrew Wang’s laboratories research with FASI focuses on understanding how xenobiotics act as allergenic adjuvants. His laboratory hypothesizes that modern xenobiotics may be acting as adjuvants sufficient for allergic sensitization. The specific aims of this research include identifying the mechanism by which xenobiotics act as allergic adjuvants and performing a retrospective single-center case-control study in children.
Qing H, Desrouleaux R, Israni-Winger K, Fogelman N, Zhang C, Rashad S, Palm NW, Sinha R, Piccioto MR, Perry RJ, Wang A. Origin and function of stress-induced IL6 in murine models. Cell. 2020. Jun 27; S0092-8674(20)30687-5. PMID: 32610084
Luan HH, Wang A, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019 Aug 22;178(5):1231-1244.e11. PMID: 31402172
Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8;166(6):1512-1525. PMID: 27610573