Daniel Mucida, Ph.D.
Professor of Immunology, Virology, & Microbiology – Rockefeller University
Distinct signals within niches of the intestinal tissue dictate the pro- versus anti-inflammatory function of immune cells
Daniel Mucida is a professor of immunology, virology, and microbiology at the Rockefeller University. His lab focuses on the characterization of tolerance and resistance pathways in the intestinal tissue and on the consequences when these processes are compromised. He and his team hypothesize that distinct signals within niches of the intestinal tissue dictate the pro- versus anti-inflammatory function of immune cells.
Daniel Mucida’s research with FASI focuses on visualizing immune-tissue cell interactions in the gut. The aims of his research are to define immune-tissue cell interactions in the intestinal epithelium during allergic responses, elucidate neuro-immune interactions in the intestinal tissue, and characterize the modulation of local systemic immunity towards luminal antigens.
Sujino T, London M, Hoytema van Konijnenburg DP, Rendon T, Buch T, Silva HM, Lafaille JJ, Reis BS, Mucida D (2016). Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation. Science 352(6293):1581-6. PMID: 27256884
Esterhazy D, Canesso MCC, Mesin L, Muller PA, de Castro TBR, Lockhart A, ElJalby M, Faria AMC, Mucida D (2019). Compartmentalized gut lymph node drainage dictates adaptive immune responses. Nature 569(7754):126-130. PMID: 30988509
Matheis F, Muller PA, Graves CL, Gabanyi I, Kerner Z, Costa-Borges D, Ahrends T, Rosenstiel P, Mucida D (2020). Adrenergic signaling in muscularis macrophages limits infection-induced neuronal loss. Cell 180(1):64-78. PMID: 31923400
Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Mármol J, Castro TBR, Furuichi M, Perkins M, Han W, Rao A, Pickard AJ, Cross JR, Honda K, Araujo I, Mucida, D (2020). Microbiota modulate sympathetic neurons via a gut-brain circuit. Nature 583(7816):441-446. PMID: 32641826
Muller PA, Matheis F, Schneeberger M, Kerner Z, Jové VY, Mucida, D (2020). Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose. Science 2020;370(6514):314-21. PMID: 32855216