Seth Rakoff-Nahoum, M.D., Ph.D.
Associate Professor of Pediatrics – Harvard University Medical School
Pediatric gastroenterology and the biological mechanisms involved in regulation in small intestinal protein transfer
Seth Rakoff-Nahoum is an assistant professor of pediatrics at Harvard Medical School and an associate physician in pediatrics in the Division of Infectious Diseases at Boston Children’s Hospital.
Seth Rakoff-Nahoum’s research with FASI focuses on pediatric gastroenterology and the biological mechanisms involved in regulation in small intestinal protein transfer. Evidence suggests that protein transfer is not a passive process, and therefore may occur for a specific physiological purpose. In order to investigate this Nahoum’s laboratory will develop model systems that would allow them to look at the mechanisms of transfer and to study its regulation. His laboratory will examine the fate of transferred dietary proteins. They will explore the properties of neonatal small intestine that enable more efficient protein transfer and because efficiency of transfer is downregulated with age, they will examine which factors control this process. Lastly, they will examine what factors (endogenous or exogenous) determine the outcome and how the outcome can be manipulated.
Rao C, Coyte KZ, Bainter W, Geha RS, Martin CR, Rakoff-Nahoum S. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature. 2021 Mar;591(7851):633-638. Epub 2021 Feb 24. PMID: 33627867
Ordovás-Montañés J, Beyaz S, Rakoff-Nahoum S, Shalek AK. Distribution and storage of inflammatory memory in barrier tissues. Nat Rev Immunol. 2020 May;20(5):308-320. PMID: 32015472