Vijay Kuchroo, D.V.M., Ph.D.

Innate Lymphoid Cells-2 and neuropeptide interaction in induction and regulation of food allergies

Vijay Kuchroo is a member of the Broad Institute, the Samuel L. Wasserstrom professor of neurology at Harvard Medical School, co-director of the Center for Infection and Immunity at the Brigham Research Institutes, and director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital. His major research interests include studies on autoimmunity and anti-tumor immunity. He first described the TIM family of genes and was co-discoverer of highly pathogenic IL-17 producing Th17 cells.

Vijay Kuchroo’s research at FASI focuses on Innate Lymphoid Cells-2 and neuropeptide interaction in induction and regulation of food allergies. The aim of his research is to determine the mechanisms by which NMU/NMUR1 interactions convert homeostatic ILCs into proinflammatory ILCs and study how CGRP regulates ILC2 function and development of food allergies.

Featured Publications
Wallrapp A, Burkett PR, Riesenfeld SJ, et al. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019;51(4):709-723.e6. PMID: 31604686

Wallrapp A, Riesenfeld SJ, Burkett PR, Kuchroo VK. Type 2 innate lymphoid cells in the induction and resolution of tissue inflammation. Immunol Rev. 2018;286(1):53-73. PMID: 30294962

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 May;24(4):417-426. PMID: 29505031

Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, Umetsu DT. The costimulatory role of TIM molecules. Immunol Rev. 2009;229(1):259-270. PMID: 19426227

Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. PMID: 31618654

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15;87(2):341-54. PMID: 26119026