Wayne Shreffler, M.D., Ph.D.
Associate Professor of Pediatrics – Harvard Medical School
Characterization of the immune response to food allergens and the early stages of allergen-induced immune reaction
Wayne Shreffler is the director of the Food Allergy Center at Massachusetts General Hospital, the division chief of pediatric allergy and immunology at Mass General Hospital of Children, a principal investigator at the Center for Immunology and Inflammatory Diseases, and an associate professor of pediatrics at Harvard Medical School.
His research and multi-disciplinary clinical program focus on characterization of the immune response to food allergens and the early stages of allergen-induced immune reaction. In collaboration with Christopher Love at MIT, he conducts research for FASI focused on single cell profiling of T cells from peanut-allergic patients and individuals suffering from the allergic disease eosinophilic esophagitis.
Ruiter B, Smith NP, Monian B, Tu AA, Fleming E, Virkud YV, Patil SU, Whittaker CA, Love JC, Shreffler WG. Expansion of the CD4+ effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity. J Allergy Clin Immunol. 2020 Jan;145(1):270-282. PMID: 31654649
Tu AA, Gierahn TM, Monian B, Morgan DM, Mehta NK, Ruiter B, Shreffler WG, Shalek AK, Love JC. TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures. Nat Immunol. 2019 Dec;20(12):1692-1699. PMID: 31745340
Patil SU, Ogunniyi AO, Calatroni A, Tadigotla VR, Ruiter B, Ma A, Moon J, Love JC, Shreffler WG. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol. 2015 Jul;136(1):125-134.e12. PMID: 25985925