Research
Our Publications
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Commensal-derived acetylcholine enhances mucosal immune education
The microbiota produces thousands of potentially bioactive small molecules1–3. High-throughput bioactivity screens of in vitro commensal cultures have exposed microbiota metabolites that shape host physiology by activating diverse G-protein-coupled receptors (GPCRs)4–7. However, owing to technical limitations, the GPCRome-wide bioactivities of… read more
FASI Principal Investigator: Noah PalmNature -
Skin inflammation and itch response are independently regulated by distinct nociceptor subsets
Common dermatological disorders are characterized by inflammation and severe itching, which represent a significant clinical challenge. The mechanisms by which nociceptive sensory neurons (nociceptors) integrate peripheral signals to modulate inflammation and itch remain unclear. Here, we showed that two subsets… read more
FASI Principal Investigator: Isaac ChiuImmunity -
Identifying microbial protease allergens through protein language model-guided homology
Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study leverages deep learning and pre-trained protein language models (pLMs) to uncover allergenic SPs in metagenomic data. First, we develop… read more
FASI Principal Investigator: Ramnik XavierCell Systems -
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells
Patients with loss-of-function DOCK8 or dominant-negative STAT3 variants have hyper-IgE syndrome, although only DOCK8 deficiency consistently presents with elevated food-specific IgE and symptomatic allergy. We previously found in mice that DOCK8 restricts the differentiation of IL-13+ T follicular helper (Tfh13)… read more
FASI Principal Investigator: Stephanie EisenbarthThe Journal of Experimental Medicine -
Mixed Signals: T Cells as Architects of IgE Immunity
Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues. T follicular helper (Tfh)… read more
FASI Principal Investigator: Stephanie EisenbarthImmunological Reviews -
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis
In atopic dermatitis (AD), skin barrier and immune dysfunction result in chronic tissue inflammation, yet our understanding of the tissue ecosystem remains incomplete. Here, we generate a multi-modal census of 280,518 cells from whole skin tissue samples from 17 adults,… read more
FASI Principal Investigator: Ramnik XavierNature Communications -
Environmentally driven immune imprinting protects against allergy
Allergic diseases are caused by overexuberant type II immune responses mounted against environmental antigens1. The allergic state is typified by the presence of allergen-reactive immunoglobulin E (IgE), which triggers mast cell degranulation upon allergen encounter, manifesting in pruritis, oedema and,… read more
FASI Principal Investigator: Ruslan MedzhitovNature -
Extrafollicular and other non-germinal center B cell responses
B cells exist as different subsets shaped by developmental cues, the activation environment, and the magnitude and nature of immune stimulus; such heterogeneity is essential for tailored immune responses. From both mouse and human studies, the past decade has seen… read more
FASI Principal Investigator: Stephanie EisenbarthThe Journal of Immunology -
High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study
Guaiac fecal occult blood test (gFOBT) is often used to evaluate evidence of food protein-induced allergic proctocolitis (FPIAP) in children in primary care and gastroenterology settings; however, it has not been validated for this diagnosis, and little is known about… read more
FASI Principal Investigator: Qian Yuan, Wayne ShrefflerJournal of Translational Gastroenterology -
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Immunoglobulin (Ig)A is the primary isotype protecting the gut barrier, yet fundamental aspects of antigen-specific IgA induction remain unknown. Gut lymphoid organs are chronically exposed to foreign antigens, are structurally different from other lymphoid tissues, and are functionally unique. This… read more
FASI Principal Investigator: Stephanie Eisenbarth, Duane WesemannImmunity -
Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states
Dietary needs are dynamic, with optimal ranges for nutrients varying over time and across physiological states. How optimal nutrient set points are established and why they are adjusted remains largely unknown. In our efforts to understand the physiology of recovery,… read more
FASI Principal Investigator: Andrew Wang, Ruslan MedzhitovCell -
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
The enteric nervous system (ENS) is a branch of the autonomous nervous system composed of neurons located across two plexi of the intestinal tract. The ENS can function semiautonomously to regulate digestion and peristalsis, through a circuit involving five main… read more
FASI Principal Investigator: Ramnik XavierScience -
Induction of tolerance to food allergens-Younger is better
Durable tolerance, or the ability to safely tolerate allergen ingestion through preventative intervention or modulation of an existing immunoglobulin E (IgE)-mediated food allergy, is vital to the treatment of food allergy. Recent insights through clinical trials and fundamental research have… read more
FASI Principal Investigator: Sarita PatilPediatric Allergy and Immunology -
Secretion of Peanut Protein With IgE Crosslinking Capacity in Human Milk
BACKGROUND: Human milk provides an infant one of the first routes of exposure to dietary antigens. A better understanding of the levels and functional capacity of maternal dietary proteins in human milk (HM) and their impact on infant food allergy… read more
FASI Principal Investigator: Sarita PatilAllergy -
Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective
Classic models of humoral immunity focus on the role of germinal centers (GCs) in producing high affinity, class switched protective antibodies. However, antibodies can also be produced through a diverse range of GC-independent pathways. Such pathways are often labeled “extrafollicular”,… read more
FASI Principal Investigator: Stephanie EisenbarthImmunological Reviews
Extrafollicular and other non-germinal center B cell responses.
Eisenbarth, S. C., Ashby, K. M., Ojo, O. A., & Williams, A. (2026).
The Journal of Immunology, 215(2), vkaf336.
Environmentally driven immune imprinting protects against allergy.
Erickson, S., Lauring, B., Cullen, J., & Medzhitov, R. (2026).
Nature, 650(8103), 987–996.
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
Fiskin, E., Eraslan, G., Alora-Palli, M. B., Jain, T., Leyva-Castillo, J. M., Kim, S., Choe, H., Lareau, C. A., Lau, H., Finan, E. P., Teixeira-Soldano, I., LaBere, B., Chu, A., Woods, B., Chou, J., Slyper, M., Waldman, J., Islam, S., Schneider, L., … Xavier, R. J. (2026).
Nature Communications, 17(1), 3194.
Identifying microbial protease allergens through protein language model-guided homology.
Thurimella, K., Wu, E., Li, C., Graham, D. B., Owens, R. M., Plichta, D. R., Sokol, C. L., Xavier, R. J., & Bacallado, S. (2026).
Cell Systems, 17(3).
Mixed Signals: T Cells as Architects of IgE Immunity.
Tierney, A. L., Bezerra, W. P., Eisenbarth, S. C., & Williams, A. (2026).
Immunological Reviews, 339(1), e70119.
Skin inflammation and itch response are independently regulated by distinct nociceptor subsets.
Voisin, T., Gheziel, N., Samrout, C. E., Martin, J., Bradaia, A., Iftinca, M., Defaye, M., Charron, A., Abdullah, N. S., Changenot, C., Gonzalez, A.-A., Depluech, A., Labit, E., Saint-Laurent, N., Staurengo-Ferrari, L., Erdogan, O., Tauber, M., Loste, A., Serhan, N., … Gaudenzio, N. (2026).
Immunity, 0(0).
Commensal-derived acetylcholine enhances mucosal immune education.
Song, D., Duncan-Lowey, B., Khetrapal, V., Hamchand, R., Deng, T., Brown, H., Wu, A., Martin, A., Bauer, K., Zhao, Y., Nguyen, M., Sonnert, N., Leopold, S., Wu, Q., Crawford, J., Palm, N.
Nature (2026).
Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics
Almanzar, N., Yang, D., Xia, J., Udit, S., Joshi, P., Adhikari, S., Hoagland, D. A., Yeung, S. T., Khairallah, C., Huerta, T., Wallrapp, A., Umans, B. D., Sarden, N., Erdogan, O., Baalbaki, N., Hou, J., Beekmayer, A., Lee, J., Meerschaert, K. A., … Chiu, I. M. (2025).
Sci. Immunol.10
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice.
Ansari, Y. S. E., Kanagaratham, C., Furiness, K. N., Brodeur, K. E., Lee, P. Y., Renz, H., & Oettgen, H. C. (2025).
Mucosal Immunology, 0(0).
Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens.
Bachtel, N. D., Cullen, J. L., Liu, M., Erickson, S. A., Kutyavin, V. I., El-Naccache, D. W., Florsheim, E. B., Lim, J., Sullivan, Z. A., Imaeda, R., Hudak, A., Zhang, C., & Medzhitov, R. (2025).
Science, 389(6760), eadp0246.
Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.
Flowers, E. M., Siniscalco, E. R., & Eisenbarth, S. C. (2025).
Immunological Reviews, 334(1), e70060.
IgG:FcγRIIb Signaling on Mast Cells Blocks Allergic Airway Inflammation.
Kanagaratham, C., El Ansari, Y. S., Furiness, K. N., & Oettgen, H. C. (2025).
International Journal of Molecular Sciences, 26(14), 6779.
Enteric neurons and immune cells shape anti-helminth immunity.
Kerner, Z., Kodra, A. L., & Mucida, D. (2025).
Trends in Parasitology, 41(4), 267–268.
High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study.
Khan, A., Jaynes, A., Ali, F., Virkud, Y., Sun, T., O’Connell, I., Shreffler, W., Yuan, Q., & Martin, V. (2025).
Journal of Translational Gastroenterology, 3(4), 229–234.
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells.
Siniscalco, E. R., Meng, H., Gabernet, G., Pacheco, G. A., Saghaei, S., Ramirez, S. I., Hills, L. B., Faraji, F., Chen, S., Yin, X., Dien, C., Hoyt, L. R., Liu, E. G., Barrett, A., Briggs, N., Williams, A., Shukla, V., Crotty, S., Wesemann, D. R., … Eisenbarth, S. C. (2025).
Immunity, 58(12), 3075-3093.e6.
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice.
Ansari, Y. S. E., Kanagaratham, C., Furiness, K. N., Brodeur, K. E., Lee, P. Y., Renz, H., & Oettgen, H. C. (2025).
Mucosal Immunology, 0(0).
A molecular basis for milk allergen immune recognition in eosinophilic esophagitis.
Dilollo, J., Hu, A., Qu, H., Canziani, K. E., Clement, R. L., McCright, S. J., Shreffler, W. G., Hakonarson, H., Spergel, J. M., Cerosaletti, K., & Hill, D. A. (2025).
Journal of Allergy and Clinical Immunology, 0(0).
Sensory neurons on guard: Roles in pathogen defense and host immunity.
Erdogan, O., Hu, X.-Q., & Chiu, I. M. (2025).
Current Opinion in Immunology, 93, 102541.
Functional diversification of dietary plant small molecules by the gut microbiome.
Kuziel, G. A., Lozano, G. L., Simian, C., Li, L., Manion, J., Stephen-Victor, E., Chatila, T., Dong, M., Weng, J.-K., & Rakoff-Nahoum, S. (2025).
Cell, S0092867425001552.
Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy.
Marini-Rapoport, O., Bhowmik, M., & Patil, S. U. (2025).
Current Allergy and Asthma Reports, 25(1), 19.
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.
Barilla, R. M., Berard, C., Sun, L., Sandhu, S., Zaghouani, S., Iyer, K. S., Altun, G., Su, C.-W., Deguine, J., Singh, V., Hou, Y., Kusumakar, K., Rutlin, M. L., Rao, M., Zaghouani, H., Shi, H. N., Xavier, R. J., & Kuchroo, V. K. (2025).
Science, 0(0), eadn9850.
Glycobiology of IgE.
Gyorgypal, A., Banerjee, S., Conroy, M. E., & Anthony, R. M. (2025).
Immunological Reviews, 331(1), e70032.
Skin damage signals mediate allergic sensitization to spatially unlinked antigen.
Waizman, D. A., Brown-Soler, I., Martin, A. L., Ma, Y., Zhou, K., Israni-Winger, K., Zhang, C., Medzhitov, R., Launay, P., Michieletto, M. F., Henao-Mejia, J., Palm, N. W., Craft, J., Eisenstein, A., & Wang, A. (2025).
Science Immunology, 10(106), eadn0688.
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour.
Yoshida, T. M., Nguyen, M., Zhang, L., Lu, B. Y., Zhu, B., Murray, K. N., Mineur, Y. S., Zhang, C., Xu, D., Lin, E., Luchsinger, J., Bhatta, S., Waizman, D. A., Coden, M. E., Ma, Y., Israni-Winger, K., Russo, A., Wang, H., Song, W., … Wang, A. (2025).
Nature, 1–10.
Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians.
Higgins, K. W., Itoigawa, A., Toda, Y., Bellott, D. W., Anderson, R., Márquez, R., & Weng, J.-K. (2025).
PLOS Genetics, 21(1), e1011533.
Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens.
Bachtel, N. D., Cullen, J. L., Liu, M., Erickson, S. A., Kutyavin, V. I., El-Naccache, D. W., Florsheim, E. B., Lim, J., Sullivan, Z. A., Imaeda, R., Hudak, A., Zhang, C., & Medzhitov, R. (2025).
Science, 389(6760), eadp0246.
Neuroimmune Circuits in Allergic Diseases.
Han, C., Zhu, X., & Sokol, C. L. (2025).
Annual Review of Immunology, 43(Volume 43, 2025), 367–394.
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.
Hoyt, L. R., Liu, E., Olson, E. C., Jacobsen, D. R., Siniscalco, E. R., Krier-Burris, R. A., Greenfield, K. G., McBride, C. D., Alfajaro, M. M., Amat, J. A. R., Zhao, Z., Xu, L., Philip, V., Verma, A., Fourati, S., Senger, D. L., Zhang, L., Bunyavanich, S., Glass, S. E., … Eisenbarth, S. C. (2025).
Science, 389(6760), eadp0240.
Systems neuroimmunology: Current bottlenecks, research priorities and future directions.
Iyer H., Benoist, C., Bilbo, S. D., Boulanger, L. M., Burton, M. D., Daniels, B. P., Deczkowska, A., Flajnik, M. F., Gareau, M. G., Grace, P. M., Irazoqui, J. E., Rosi, S., Salinas, I., Schaefer, A., Sokol, C. L., Williams, D. W., & Klein, R. S. (2025).
Nature Immunology, 26(3), 325–329.
Integrated control of leukocyte compartments as a feature of adaptive physiology.
Jaschke, N. P., & Wang, A. (2025).
Immunity, 58(2), 279–294.
Neurogenic inflammation and itch in barrier tissues.
Liu, R., Buttaci, D. R., & Sokol, C. L. (2025).
Seminars in Immunology, 77, 101928.
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.
Marini-Rapoport, O., Andrieux, L., Keswani, T., Zong, G., Duchen, D., Yaari, G., Min, J., Lytle, I. R., Rosenberg, A. F., Fucile, C., Kobie, J. J., Piepenbrink, M. S., Sun, T., Martin, V. M., Yuan, Q., Shreffler, W. G., Seppo, A. E., Järvinen, K. M., Loeffler, J. R., … Patil, S. U. (2025).
Science Translational Medicine, 17(802), eadw4148.
Epitope-Specific Antibodies in Allergic Disease and Clinical Tolerance.
Marini-Rapoport, O., Bhowmik, M., Keswani, T., & Patil, S. U. (2025).
Immunological Reviews, 332(1), e70042.
Secretion of Peanut Protein With IgE Crosslinking Capacity in Human Milk.
Burris, A. D., Diaz, N., Meddings, J. B., Karmakar, B., Keswani, T., Patil, S. U., Seppo, A. E., & Järvinen, K. M. (2025).
Allergy.
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis
Das, M., Alasharee, M., Woods, B., Mukherjee, S., Kim, S., Elkins, M., Ngo, J., Magin, L., Timilshina, M., Leyva-Castillo, J. M., Murphy, K. M., Anthony, R. M., Laureano, A. F. S., Murphy, G. F., McNamee, S., Brombacher, F., Hogan, S. P., Turner, J. R., Abtahi, S., … Geha, R. S. (2025).
Immunity, 0(0).
Extrafollicular and Other Non-Germinal Center B Cell Responses: An Evolutionary Perspective.
Flowers, E. M., Siniscalco, E. R., & Eisenbarth, S. C. (2025).
Immunological Reviews, 334(1), e70060.
Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states.
Jaschke, N. P., Luchsinger, J. R., Chen, Z., Wulfmeyer, V. C., de la Rosa, X., Hahn, O., Zhang, C., Bachtel, N. D., Cullen, J. L., Rachner, T. D., Medzhitov, R., Rinschen, M. M., Wu, C., & Wang, A. (2025).
Cell.
Induction of tolerance to food allergens-Younger is better.
Smeekens, J. M., Kulis, M. D., Kim, E. H., & Patil, S. U. (2025).
Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology, 36(10), e70193.
Regional encoding of enteric nervous system response to microbiota and type 2 inflammation.
Tan P, Jaiswal A, Murphy SP, Brown EM, Wheeler H, Su CW, Finan EP, Guadalupe JJ, Shi HN, Graham DB, Delorey TM, Deguine J, Xavier RJ (2025).
Science.
Identification of antigen-presenting cell–T cell interactions driving immune responses to food.
Canesso, M. C. C., Castro, T. B. R., Nakandakari-Higa, S., Lockhart, A., Luehr, J., Bortolatto, J., Parsa, R., Esterházy, D., Lyu, M., Liu, T.-T., Murphy, K. M., Sonnenberg, G. F., Reis, B. S., Victora, G. D., & Mucida, D. (2024).
Science, 0(0), eado5088.
Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to pneumococcal vaccination.
Morgan, D. M., Zhang, Y. J., Kim, J.-H., Murillo, M., Singh, S., Loschko, J., Surendran, N., Sekulovic, O., Feng, E., Shi, S., Irvine, D. J., Patil, S. U., Kanevsky, I., Chorro, L., & Christopher Love, J. (2024).
Communications Biology, 7, 1208.
Neutralizing IgG4 antibodies are a biomarker of sustained efficacy after peanut oral immunotherapy
Keswani, T., LaHood, N. A., Marini-Rapoport, O., Karmakar, B., Andrieux, L., Reese, B., Sneed, S. L., Pedersen, L. C., Mueller, G. A., & Patil, S. U. (2024).
The Journal of Allergy and Clinical Immunology, S0091-6749(24)00233-1.
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies
Min, J., Keswani, T., LaHood, N. A., Lytle, I. R., Marini-Rapoport, O., Andrieux, L., Sneed, S. L., Edwards, L. L., Petrovich, R. M., Perera, L., Pomés, A., Pedersen, L. C., Patil, S. U., & Mueller, G. A. (2024)
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology, 54(1), 46–55.
Design of an Ara h 2 hypoallergen from conformational epitopes
Min, J., Keswani, T., LaHood, N.A., Lytle, I.R., Marini-Rapoport, O., Andreiuex, L., Sneed, S. L., Edwards, L.L., Petrovich, R.M., Perera L., Pomés, A., Pedersen, L.C., Patil, S.U., Mueller, G.A. (2024)
Clin Exp Allergy. 2024;00:1-10.
Sensory neurons: An integrated component of innate immunity
Deng, L., Gillis, J. E., Chiu, I. M., & Kaplan, D. H. (2024)
Immunity, 57(4), 815–831.
Sensory neuronal control of skin barrier immunity
Feng, X., Zhan, H., & Sokol, C. L. (2024)
Trends in Immunology, 45(5), 371–380.
The neuroimmune CGRP–RAMP1 axis tunes cutaneous adaptive immunity to the microbiota
Kulalert, W., Wells, A. C., Link, V. M., Lim, A. I., Bouladoux, N., Nagai, M., Harrison, O. J., Kamenyeva, O., Kabat, J., Enamorado, M., Chiu, I. M., & Belkaid, Y. (2024)
Proceedings of the National Academy of Sciences, 121(11), e2322574121.
Basophils are important for development of allergic skin inflammation
Leyva-Castillo, J.-M., Vega-Mendoza, D., Strakosha, M., Deng, L., Choi, S., Miyake, K., Karasuyama, H., Chiu, I. M., Phipatanakul, W., & Geha, R. S. (2024)
The Journal of Allergy and Clinical Immunology, 153(5), 1344-1354.e5.
A vagal reflex evoked by airway closure
Schappe, M. S., Brinn, P. A., Joshi, N. R., Greenberg, R. S., Min, S., Alabi, A. A., Zhang, C., & Liberles, S. D. (2024)
Nature, 627(8005), 830–838.
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
Ding, J., Garber, J. J., Uchida, A., Lefkovith, A., Carter, G. T., Vimalathas, P., Canha, L., Dougan, M., Staller, K., Yarze, J., Delorey, T. M., Rozenblatt-Rosen, O., Ashenberg, O., Graham, D. B., Deguine, J., Regev, A., & Xavier, R. J. (2024)
Nature Communications, 15(1), 3344.
Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy
Furiness, K. N., El Ansari, Y. S., Oettgen, H. C., & Kanagaratham, C. (2024)
Frontiers in Allergy, 5, 1389669.
Nutrient-derived signals regulate eosinophil adaptation to the small intestine
Kutyavin, V., Korn, L. L., & Medzhitov, R. (2024)
Proceedings of the National Academy of Sciences, 121(5), e2316446121.
Adverse Food Reactions: Physiological and Ecological Perspectives
Korn, L. L., Kutyavin, V. I., Bachtel, N. D., & Medzhitov, R. (2024)
Annual Review of Nutrition
TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
Kratchmarov, R., Djeddi, S., Dunlap, G., He, W., Jia, X., Burk, C. M., Ryan, T., McGill, A., Allegretti, J. R., Kataru, R. P., Mehrara, B. J., Taylor, E. M., Agarwal, S., Bhattacharyya, N., Bergmark, R. W., Maxfield, A. Z., Lee, S., Roditi, R., Dwyer, D. F., Brennan, P. J. (2024)
Nature Immunology, 25(5), 902–915.
IL-4 acts on skin derived dendritic cells to promote the Th2 response to cutaneous sensitization and the development of allergic skin inflammation
Leyva-Castillo, J. M., Das, M., Strakosha, M., McGurk, A., Artru, E., Kam, C., Alasharee, M., Wesemann, D. R., Tomura, M., Karasuyama, H., Brombacher, F., & Geha, R. S. (2024)
Journal of Allergy and Clinical Immunology, 0(0).
Dendritic Cells in Food Allergy, Treatment, and Tolerance
Liu, E. G., Yin, X., Siniscalco, E., & Eisenbarth, S. C. (2024)
Journal of Allergy and Clinical Immunology, 0(0).
Sensory sentinels: Neuroimmune detection and food allergy
Matatia, P. R., Christian, E., & Sokol, C. L. (2024)
Immunological Reviews.
A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut
Zhu, Y., Meerschaert, K. A., Galvan-Pena, S., Bin, N.-R., Yang, D., Basu, H., Kawamoto, R., Shalaby, A., Liberles, S. D., Mathis, D., Benoist, C., & Chiu, I. M. (2024)
Science, 385(6708), eadk1679.
Stress-sensitive neural circuits change the gut microbiome via duodenal glands
Chang, H., Perkins, M. H., Novaes, L. S., Qian, F., Zhang, T., Neckel, P. H., Scherer, S., Ley, R. E., Han, W., & Araujo, I. E. de. (2024)
Cell, 0(0).
A γδ T cell–IL-3 axis controls allergic responses through sensory neurons
Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A.-C., & Sokol, C. L. (2024)
Nature, 1–7.
Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy
LaHood, N. A., Min, J., Keswani, T., Richardson, C. M., Amoako, K., Zhou, J., Marini-Rapoport, O., Bernard, H., Hazebrouck, S., Shreffler, W. G., Love, J. C., Pomes, A., Pedersen, L. C., Mueller, G. A., & Patil, S. U. (2023)
The Journal of Clinical Investigation, 133(2), e164501.
Intraepithelial Lymphocytes of the Intestine
Lockhart, A., Mucida, D., & Bilate, A. M. (2024)
Annual Review of Immunology, 42(1), 289–316.
Neuroimmune Interactions in the Intestine
Wallrapp, A., & Chiu, I. M. (2024)
Annual Review of Immunology, 42(1), 489–519.
An airway-to-brain sensory pathway mediates influenza-induced sickness
Bin, N.-R., Prescott, S. L., Horio, N., Wang, Y., Chiu, I. M., & Liberles, S. D. (2023)
Nature, 615(7953), 660–667
Immune sensing of food allergens promotes avoidance behaviour. Nature
Florsheim, E. B., Bachtel, N. D., Cullen, J. L., Lima, B. G. C., Godazgar, M., Carvalho, F., Chatain, C. P., Zimmer, M. R., Zhang, C., Gautier, G., Launay, P., Wang, A., Dietrich, M. O., & Medzhitov, R. (2023)
Nature, 620(7974), Article 7974
Enteroendocrine cell lineages that differentially control feeding and gut motility
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