José Ordovás-Montañés, Ph.D.
Assistant Professor – Harvard Medical School
The Ordovás-Montañés laboratory is committed to applying single-cell approaches to help understand the cellular memory networks which promote food allergy.
José Ordovás-Montañés, Ph.D. is a research faculty member at Boston Children’s Hospital, an assistant professor at HMS, associate member at the Broad Institute, and principal investigator at HSCI. He is a New York Stem Cell Foundation Robertson Investigator. His research focuses on how inflammation drives memory formation in barrier tissues, in order to program and re-program them in disease. He is particularly interested in identifying and testing human disease-relevant cell states.
The Ordovás-Montañés laboratory is committed to applying single-cell approaches to help understand the cellular memory networks which promote food allergy. Their research with FASI focuses on applying their tools, such as single-cell RNA-sequencing, to measure sensitization and challenge within barrier tissues at high cellular resolution. The goal of their FASI project is to catalyze food allergy research in their emergent laboratory and collaborate with FASI colleagues to address ongoing challenges regarding the understanding of how food allergies collectively impact the cell types and subsets of the intestine in pre-clinical models and human studies. This project will provide a critical resource for the FASI community, with data shared rapidly amongst colleagues.
Featured Publications:
Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018 Nov 15;175(5):1307-1320.e22. PMID: 30392957
Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH 2nd, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 Aug;560(7720):649-654. PMID: 30135581